Pig kidneys performing effectively in two brain-dead patients

Research
By Editor_1
Tissue from the pig kidney is examined and removed in preparation for transplant into human recipient -Joe Carrotta/NYU Langone Health
By Roni Caryn Rabin

Surgeons in Birmingham, Alabama, and New York City on Wednesday (16) reported advances in the transplantation of organs obtained from pigs that have been genetically modified to prevent rejection after they are implanted in humans.

Researchers at the University of Alabama at Birmingham published a peer-reviewed study showing that modified pig kidneys performed complex life-sustaining functions in a brain-dead patient for a full week.

In an apparent response, surgeons at NYU Langone Health announced that a kidney from a genetically modified pig continued to function well after 32 days in a brain-dead patient maintained on a ventilator, the longest period for such an experiment.

The patient has shown no signs of rejecting the organ, said Dr Robert Montgomery, director of the NYU Langone Transplant Institute. But the research has not yet been published in a scientific journal.

Why It Matters: An inadequate supply of donor organs

The research is part of a radical scientific effort to develop an alternative source of transplant organs for Americans whose kidneys, hearts and other organs have failed.

The greatest need is for kidneys. More than 800,000 Americans have kidney failure, and more than 100,000 are on a waiting list for a transplant. Kidney dialysis can keep patients alive, but the gold standard treatment is an organ transplant.

Yet fewer than 25,000 kidney transplants are performed each year because of a scarcity of human donor organs. Thousands of people on the waiting list die each year.

“A lot of folks think dialysis is an appropriate alternative, but people die on dialysis,” said Dr Jayme Locke, director of UAB’s Comprehensive Transplant Institute and a lead author of the new report.

A number of studies last year demonstrated that pig kidneys that had been transplanted into brain-dead individuals made urine, an essential function, for short periods of time. But the UAB study is the first to clearly show that the organs also filter creatinine, a byproduct of muscle contractions that must be removed from the blood.

“The really new finding here is that these pig kidneys can clear enough creatinine to support an adult human,” Locke said. The UAB paper was published Wednesday as a research letter in JAMA Surgery.

The kidney performs numerous functions, among them balancing the body’s fluids, regulating blood pressure and controlling pH levels. “If you want to have life-sustaining kidney function, the kidneys have to do more than just make urine,” Locke said.

Background: Animal organs may be a solution to the shortage

Xenotransplantation, the transplantation of animal organs into humans, has long been a goal of surgeons. Recent advances in cloning and genetic engineering have led to rapid breakthroughs.

In 2021, surgeons at NYU Langone Health announced they had attached a kidney from a genetically modified pig to a brain-dead individual who was maintained on a ventilator. A few months later, researchers at the University of Maryland transplanted a heart from a genetically modified pig into a 57-year-old patient with heart failure. He died two months later, and traces of a virus known to infect pigs were found in the organ.

Locke and her colleagues reported last year that they had for the first time successfully transplanted kidneys from a genetically modified pig into the abdomen of a brain-dead man.

The organs used in the experiments in Alabama and New York are slightly different, though both were derived from pigs provided by Revivicor, a subsidiary of United Therapeutics Corp., a biotech company.

The kidneys used at UAB came from pigs that had undergone 10 gene modifications, while the kidneys used at NYU Langone Health had only one genetic modification. The latter procedure also calls for embedding the pig’s thymus gland, which is responsible for educating the immune system, underneath the outer layer of the new kidney to prevent an immune-system attack.

What’s Next: A clinical trial in humans

So far, transplants of genetically modified pig kidneys have been made only to brain-dead patients. Locke and her colleagues are in discussions with the Food and Drug Administration about launching a clinical trial in live patients.

-New York Times

 

 

 

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